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NABP FPGEE - Foreign Pharmacy Graduate Equivalency Examination

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Total 426 questions

The organophosphates commonly found in insecticides are thought to act by which of the following mechanisms?

A.

Combining with acetylcholine

B.

Potentiating the action of acetylcholinesterase

C.

Forming a very stable complex with acetylcholinesterase

D.

Reacting at the cholinergic receptor

E.

Preventing the release of acetylcholine from the nerve ending

Example of methyl xanthine used in the treatment of respiratory complications include:

A.

Theophyllin

B.

Terbutaline

C.

Ipratropium

D.

Zafirlukast

E.

Salmeterol

Salbutamol is short acting β2-agonists that may be used in the treatment of which of the following asthma type?

A.

Mild asthma

B.

Emergency asthma

C.

Severe intermittent asthma

D.

Moderate asthma

E.

All kind of asthma

Drug that inhibits xanthine oxidase and affect the metabolism of 6-mercaptopurine:

A.

Sulfinpyrazone

B.

Allopurinol

C.

Penicillamine

D.

Purinethol

E.

Celecoxib

The skeletal structure of the hipbone includes the:

I ilium

II ischium

III pubis

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

Once daily dosing of aminoglycosides is effective due to:

A.

prolonged residence of the antibiotic in the body

B.

post-antimicrobial effect

C.

enhanced tissue accumulation

D.

reduced renal clearance

E.

higher peak-trough differences

In the treatment of rheumatoid arthritis, the salicylates:

A.

Stop and often reverse the progressive joint involvement.

B.

Specifically reverse the cause of the disease.

C.

Provide only analgesic and anti-inflammatory effects.

D.

Are effective because they are uricosuric agents.

E.

Are more effective when given with allopurinol.

The major pathway for the biotransformation of the following compound is by hydrolysis. Identify the site which would be most susceptible to hydrolysis.

A.

A

B.

B

C.

C

D.

D

E.

E

Mechanisms of drug interactions with acetylsalicylic acid (ASA. include:

A.

induction of microsomal enzymes

B.

inhibition of microsomal enzymes

C.

inhibition of liposomal enzymes

D.

displacement of other drugs bound to serum albumin

E.

enhanced platelet aggregation

A patient purchasing sublingual nitroglycerin tablets should be told to store the medication:

A.

in the refrigerator

B.

in a plastic vial with a childproof cap

C.

with the original cotton

D.

in an amber glass bottle with a metal cap

E.

in a warm, dry place