PTCB PTCE - Pharmacy Technician Certification (CPhT) Exam

Comprehensive and Detailed Step-by-Step Explanation:

OnceBasaglar insulin pensare opened, they must bediscarded after 28 dayseven if insulin remains, as potency decreases.

📌Explanation of Answer Choices:✅D. 28 days→Correct.FDA-approved discard time for Basaglar.❌A. 1 day→ Incorrect.Too short.kabtak chaoiyue❌B. 7 days→ Incorrect.Too short.❌C. 14 days→ Incorrect.Incorrect expiration timeframe.

📌Reference:

FDA Basaglar Storage Guidelines

PTCB Exam: Medication Storage and Expiration

Bupropion (Wellbutrin, Zyban) requires a Medication Guide due to risks of suicidal thoughts and neuropsychiatric effects.

Medication Guides are FDA-required leaflets given with specific medications that have serious risks.

Examples of Medications Requiring a Medication Guide:

Antidepressants (e.g., SSRIs, SNRIs, bupropion) → Suicide risk

NSAIDs → GI bleeding risk

Opioids → Addiction risk

Fluoroquinolones → Tendon rupture risk

📌Reference:FDA Medication Guide Requirements, ISMP Patient Safety Guidelines.

Risedronate (Actonel) is a bisphosphonate used for osteoporosis.

It can causehypocalcemia (low calcium levels)byinhibiting bone resorption.

Patients must take it witha full glass of water and remain upright for 30 minutesto preventesophageal irritation.

📌Reference:FDA Bisphosphonate Warnings, PTCB Drug Counseling Guidelines.

Enteric-coated (EC) tabletsare designed todelay drug release until they reach the intestine, preventing stomach irritation and degradation by gastric acid. The coatingresists stomach acidbut dissolves in thehigher pH environment of the intestines.

Aspirin EC(prevents stomach irritation)

Pantoprazole EC(proton pump inhibitor)

Diclofenac EC(NSAID)

A. Buffered→ Incorrect; buffered formulationsneutralize stomach acidbut do not delay release until the intestines.

C. Controlled release→ Incorrect; controlled-release formulationsgradually release medicationover time but are not specifically designed tobypass the stomach.

D. Buccal→ Incorrect; buccal tablets dissolve in thecheek mucosa, bypassing the digestive system entirely.

Examples of Enteric-Coated Medications:Other Answer Choices Explained:References:

FDA Drug Formulation Guidelines

USP <795> Drug Release & Absorption Standards

PTCB PTCE Exam Content Outline (Pharmaceutical Dosage Forms & Drug Release Mechanisms)

5-FU (Fluorouracil) is a chemotherapy drugused forcolon, breast, and skin cancers.

It is apyrimidine analogthatprevents cancer cell DNA replication.

Why Other Options Are Incorrect:

A. Fluocinonide?❌Topical corticosteroid for skin conditions.

B. Fluoxetine (Prozac)?❌SSRI antidepressant.

C. Fluocinolone?❌Topical corticosteroid.

📌Reference:National Cancer Institute Chemotherapy Guide, PTCB Oncology Medications.

Methotrexateis achemotherapy agentand animmunosuppressantused for cancer and autoimmune diseases.

It is classified ashazardous pharmaceutical wasteunderResource Conservation and Recovery Act (RCRA)due to itstoxicity.

It must be disposed of followingEPA guidelines for hazardous waste disposal.

📌Reference:RCRA hazardous waste disposal regulations;USP <800> guidelines for hazardous drugs.