NABP FPGEE - Foreign Pharmacy Graduate Equivalency Examination

May induce mild hypotension and worsen congestive heart failure in some patients. However, most CHF patients can tolerate it.

Duration of action is usually several days.

Has been show to be more effective than six other agents in preventing arrhythmia recurrence and death in patients with ventricular tachyarrhythmias.

Is effective against erythrocytic forms.

Used in emergency setting during attempted resuscitation when lidocaine and cardioversion have failed.

May increase heart rate

Decreases triglycerides by 10-20%

May decrease heart rate

Inhibits basal gastric acid secretion

Decreases AV conduction

Reduces calcium influx into neurons

Inhibits calcineurin

Inhibits phospholipase C

Inhibits phospholipid synthesis

Induces DNA damage under anaerobic conditions

CHF

Tachycardia

AV block

Sedative appearance

Ester hydrolysis

N-oxidation

Glucuronide conjugation

A & B

All of the above

Cytochrome P450

Alcohol Dehydrogenase

Glucuronyl Transferase

Sulfotransferase

All of the above

Mutation of viral DNA polymerase

Mutations of viral protease

Mutation of thymidilate synthase decreasing its affinity for the drug's active metabolite

Tolerance

Mutation of viral reverse transcriptase

In Tuberculosis

Migraine prophylaxis

Tricyclic antidepressant poisoning

Broad spectrum antibacterial agent

Asthma

The removal of drug is independent of drug concentration

Cl = Elimination rate/Cp

t1/2 = .7VD/Cl

All are true

Insomnia

Cyanide poisoning

Cardiac arrest

Inflammation

Subarachnoid hemorrhage